CETYLOYL CHLORIDE
Hexadecanoyl chloride;Palmitoyl chloride
CAS: 112-67-4
Molecular Formula: C16H31ClO
CETYLOYL CHLORIDE - Names and Identifiers
| Name | Hexadecanoyl chloride Palmitoyl chloride |
| Synonyms | CETYLOYL CHLORIDE Palmitoyl chloride HEXADECANOYL CHLORIDE Hexadecanoyl chloride PALMITIC ACID CHLORIDE hexadecanoicacid,chloride PALMITOYL CHLORIDE FOR SYNTHESIS Palm acetyl chlorine(14 acetyl chlorine) |
| CAS | 112-67-4 |
| EINECS | 203-996-7 |
| InChI | InChI=1/C16H31ClO/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3 |
CETYLOYL CHLORIDE - Physico-chemical Properties
| Molecular Formula | C16H31ClO |
| Molar Mass | 274.87 |
| Density | 0.906 g/mL at 25 °C (lit.) |
| Melting Point | 11-13 °C (lit.) |
| Boling Point | 88-90 °C/0.2 mmHg (lit.) |
| Flash Point | >230°F |
| Water Solubility | Decomposition |
| Solubility | Chloroform (Sparingly), Ethyl Acetate (Slightly) |
| Vapor Presure | 0.000261mmHg at 25°C |
| Appearance | Liquid |
| Specific Gravity | 0.905 |
| Color | Clear |
| BRN | 972409 |
| Storage Condition | Store below +30°C. |
| Stability | Moisture Sensitive |
| Sensitive | Moisture Sensitive |
| Refractive Index | n20/D 1.452(lit.) |
| Physical and Chemical Properties | Colorless liquid. Melting Point 11-12 ℃, boiling point 12 ℃, boiling point 199 ℃(2.6kPa),194.5 ℃(2.27kPa). Refractive index 1.4512. Miscible with organic solvents, soluble in ether. Decomposition in water and ethanol. |
| Use | Used as an intermediate in organic synthesis |
CETYLOYL CHLORIDE - Risk and Safety
| Hazard Symbols | C - Corrosive |
| Risk Codes | R14 - Reacts violently with water R34 - Causes burns R29 - Contact with water liberates toxic gas |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S43 - In case of fire use ... (there follows the type of fire-fighting equipment to be used.) S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S8 - Keep container dry. |
| UN IDs | UN 3265 8/PG 2 |
| WGK Germany | 1 |
| FLUKA BRAND F CODES | 9-21 |
| TSCA | Yes |
| HS Code | 2915 90 70 |
| Hazard Class | 8 |
| Packing Group | II |
| Toxicity | LD50 orally in Rabbit: > 2000 mg/kg |
CETYLOYL CHLORIDE - Nature
Open Data Verified Data
colorless liquid. Soluble in ether, decomposition in ethanol and water. Melting Point 11~12 °c. Boiling point of 199 deg C (2. 6kPa). Refractive index 1.4512.
Last Update：2024-01-02 23:10:35
CETYLOYL CHLORIDE - Preparation Method
Open Data Verified Data
with palmitic acid as raw material, benzene as solvent, sulfur dioxide and hydrogen chloride were recovered by thionyl chloride chlorination. The reaction product was rectified under reduced pressure to recover excess thionyl chloride and benzene, and then cooled, the finished product was obtained.
Last Update：2022-01-01 10:32:25
CETYLOYL CHLORIDE - Use
Open Data Verified Data
This product is an intermediate in organic synthesis. In medicine for the preparation of chloramphenicol and tasteless chloramphenicol and other sixteen carbonate.
Last Update：2022-01-01 10:32:24
CETYLOYL CHLORIDE - Safety
Open Data Verified Data
- This product is toxic. Highly corrosive. Hydrogen chloride gas is generated in contact with water, which can cause burns. When it is spattered on the skin, it should be rinsed with a large amount of clear water, or alternatively washed with lime water and 1% ammonia water. The workshop should be well ventilated. Production equipment should be sealed, and operators should wear protective equipment.
- sealed packaging in glass bottle with wood frame protection. Transport according to the regulations of toxic chemicals.
Last Update：2022-01-01 10:32:25
CETYLOYL CHLORIDE - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Use | This product is an intermediate for organic synthesis, which is used in the pharmaceutical industry to prepare antibiotics such as chloramphenicol, hexadeccarbonate and tasteless chloramphenicol. used as intermediate in organic synthesis |
| production method | is obtained by reacting palmitic acid with thionyl chloride. Palmitic acid, thionyl chloride and benzene were added to the reaction pot and heated. The reaction temperature finally reached 80-85 °c and was maintained for 2H. Thionyl chloride and benzene were then recovered at 90 °c (21.3kPa) to yield hexadecyl chloride. Raw material consumption quota: palmitic acid 880kg/t, thionyl chloride 580kg/t, benzene 200kg/t. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 20:49:11
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View History
CETYLOYL CHLORIDE
2,5-二氨基苯磺酸
mono (2-ethylhexyl) phosphate
2-({[(9H-芴-9-基)甲氧基]羰基}[2-(4-甲氧基苯基)乙基]氨基)乙酸
INTERMEDIATES FORBUTAMITRATE,FENBATRAZATE,PHENETURIDE
(3-溴吡啶-4-基)氨基甲酸叔丁酯
SILANISATION SOLUTION
Pediococcus
Light stabilizer 3853
Sulfurol decanoate
2,5-二氨基苯磺酸
mono (2-ethylhexyl) phosphate
2-({[(9H-芴-9-基)甲氧基]羰基}[2-(4-甲氧基苯基)乙基]氨基)乙酸
INTERMEDIATES FORBUTAMITRATE,FENBATRAZATE,PHENETURIDE
(3-溴吡啶-4-基)氨基甲酸叔丁酯
SILANISATION SOLUTION
Pediococcus
Light stabilizer 3853
Sulfurol decanoate